Tau-mediated synaptic dysfunction is coupled with HCN channelopathy.

ABSTRACT:

Introduction

In tauopathies, altered tau processing correlates with impairments in synaptic density and function. Changes in hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contribute to disease-associated abnormalities in multiple neurodegenerative diseases.

Methods

To investigate the link between tau and HCN channels, we performed histological, biochemical, ultrastructural, and functional analyses of hippocampal tissues from Alzheimer's disease (AD), age-matched controls, Tau35 mice, and/or Tau35 primary hippocampal neurons.

Results

Expression of specific HCN channels is elevated in post mortem AD hippocampus. Tau35 mice develop progressive abnormalities including increased phosphorylated tau, enhanced HCN channel expression, decreased dendritic b

SUBMITTER: Goniotaki D 

PROVIDER: S-EPMC11350046 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature