Lung function in relation to brain aging and cognitive transitions in older adults: A population-based cohort study.

ABSTRACT:

Background

We investigated the association of peak expiratory flow (PEF) with dementia; cognitive impairment, no dementia (CIND); and transition from CIND to dementia, and possible underlying neuropathological mechanisms.

Methods

A population-based cohort of adults aged 60+ was followed over 15 years to detect dementia (Diagnostic and Statistical Manual of Mental Disorders, 4th edition criteria), CIND (assessed through a cognitive battery), and progression from CIND to dementia, in relation to baseline PEF observations. A subsample (n = 462) had 6-year follow-up data on brain magnetic resonance imaging markers of neurodegeneration and small vessel disease.

Results

In fully adjusted models, poor PEF performance (< 10th vs. ≥ 80th percentile) was associated with increas

SUBMITTER: Grande G 

PROVIDER: S-EPMC11350049 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature