KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults.

ABSTRACT:

Introduction

We examined whether the aging suppressor KLOTHO gene's functionally advantageous KL-VS variant (KL-VS heterozygosity [KL-VS_HET]) confers resilience against deleterious effects of aging indexed by cerebrospinal fluid (CSF) biomarkers of neuroinflammation (interleukin-6 [IL-6], S100 calcium-binding protein B [S100B], triggering receptor expressed on myeloid cells [sTREM2], chitinase-3-like protein 1 [YKL-40], glial fibrillary acidic protein [GFAP]), neurodegeneration (total α-synuclein [α-Syn], neurofilament light chain protein), and synaptic dysfunction (neurogranin [Ng]).

Methods

This Alzheimer disease risk-enriched cohort consisted of 454 cognitively unimpaired adults (M_age = 61.5 ± 7.75). Covariate-adjusted multivariate regression examine

SUBMITTER: Driscoll IF 

PROVIDER: S-EPMC11350058 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature