Cerebral arteriolosclerosis, lacunar infarcts, and cognition in older Black adults.

ABSTRACT:

Introduction

Older Black adults are at risk of cerebral small vessel disease (CSVD), which contributes to dementia risk. Two subtypes of CSVD, arteriolosclerosis and ischemic lacunar infarcts, have been independently linked to lower cognition and higher dementia risk, but their combined effects on cognition in older Black adults are unclear.

Methods

Mixed models were used to examine the associations of in vivo measures of arteriolosclerosis (ARTS) and ischemic lacunar infarcts to cognitive level and change in 370 older Black adults without dementia.  RESULTS: Modeled together, higher ARTS load accounted for lower levels of global cognition, episodic memory, semantic memory, and perceptual speed, whereas higher infarct load accounted for lower levels of working memory. There

SUBMITTER: Fleischman DA 

PROVIDER: S-EPMC11350059 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature