Host specificity and cophylogeny in the "animal-gut bacteria-phage" tripartite system.

ABSTRACT: Cophylogeny has been identified between gut bacteria and their animal host and is highly relevant to host health, but little research has extended to gut bacteriophages. Here we use bee model to investigate host specificity and cophylogeny in the "animal-gut bacteria-phage" tripartite system. Through metagenomic sequencing upon different bee species, the gut phageome revealed a more variable composition than the gut bacteriome. Nevertheless, the bacteriome and the phageome showed a significant association of their dissimilarity matrices, indicating a reciprocal interaction between the two kinds of communities. Most of the gut phages were host generalist at the viral cluster level but host specialist at the viral OTU level. While the dominant gut bacteria Gilliamella and Snodgrassella exhib

SUBMITTER: Feng Y 

PROVIDER: S-EPMC11350085 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature