Drp1 depletion protects against ferroptotic cell death by preserving mitochondrial integrity and redox homeostasis.

ABSTRACT: Mitochondria are highly dynamic organelles which undergo constant fusion and fission as part of the mitochondrial quality control. In genetic diseases and age-related neurodegenerative disorders, altered mitochondrial fission-fusion dynamics have been linked to impaired mitochondrial quality control, disrupted organelle integrity and function, thereby promoting neural dysfunction and death. The key enzyme regulating mitochondrial fission is the GTPase Dynamin-related Protein 1 (Drp1), which is also considered as a key player in mitochondrial pathways of regulated cell death. In particular, increasing evidence suggests a role for impaired mitochondrial dynamics and integrity in ferroptosis, which is an iron-dependent oxidative cell death pathway with relevance in neurodegeneration. In this

SUBMITTER: Tang S 

PROVIDER: S-EPMC11350090 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature