Association of pathogenic determinants of Fusobacterium necrophorum with bacteremia, and Lemierre's syndrome.

ABSTRACT: Fusobacterium necrophorum is a Gram-negative anaerobic bacterium responsible for localized infections of the oropharynx that can evolve into bacteremia and/or septic thrombophlebitis of the jugular vein or peritonsillar vein, called Lemierre's syndrome. To identify microbial genetic determinants associated with the severity of this life-threatening disease, 70 F. necrophorum strains were collected and grouped into two categories according to the clinical presentation: (i) localized infection, (ii) bacteremia with/without Lemierre's syndrome. Comparative genomic analyses revealed two clades with distinct genetic content, one clade being significantly enriched with isolates from subjects with bacteremia. To identify genetic determinants contributing to F. necrophorum pathogenicity, genomic i

SUBMITTER: Carrara A 

PROVIDER: S-EPMC11350119 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature