Effects of a multidomain intervention against cognitive decline on dementia risk profiles - Results from the AgeWell.de trial.

ABSTRACT:

Introduction

Dementia risk scores constitute promising surrogate outcomes for lifestyle interventions targeting cognitive function. We investigated whether dementia risk, assessed using the LIfestyle for BRAin health (LIBRA) index, was reduced by the AgeWell.de intervention.

Methods

Secondary analyses of the AgeWell trial, testing a multicomponent intervention (including optimization of nutrition, medication, and physical, social, and cognitive activity) in older adults with increased dementia risk. We analyzed data from n = 461 participants with complete information on risk/protective factors comprised by LIBRA at the 24-month follow-up. Intervention effects on LIBRA and LIBRA components were assessed using generalized linear models.

Results

The intervention reduced

SUBMITTER: Zulke AE 

PROVIDER: S-EPMC11350131 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature