Stress testing the Centiloid: Precision and variability of PET quantification of amyloid pathology.

ABSTRACT:

Introduction

Assessing the potential sources of bias and variability of the Centiloid (CL) scale is fundamental for its appropriate clinical application.

Methods

We included 533 participants from AMYloid imaging to Prevent Alzheimer's Disease (AMYPAD DPMS) and Alzheimer's Disease Neuroimaging Initiative (ADNI) cohorts. Thirty-two CL pipelines were created using different combinations of reference region (RR), RR and target types, and quantification spaces. Generalized estimating equations stratified by amyloid positivity were used to assess the impact of the quantification pipeline, radiotracer, age, brain atrophy, and harmonization status on CL.

Results

RR selection and RR type impact CL the most, particularly in amyloid-negative individuals. The standard CL pipeline

SUBMITTER: Shekari M 

PROVIDER: S-EPMC11350134 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature