Sex and gender differences in cognitive resilience to aging and Alzheimer's disease.

ABSTRACT: Sex and gender-biological and social constructs-significantly impact the prevalence of protective and risk factors, influencing the burden of Alzheimer's disease (AD; amyloid beta and tau) and other pathologies (e.g., cerebrovascular disease) which ultimately shape cognitive trajectories. Understanding the interplay of these factors is central to understanding resilience and resistance mechanisms explaining maintained cognitive function and reduced pathology accumulation in aging and AD. In this narrative review, the ADDRESS! Special Interest Group (Alzheimer's Association) adopted a multidisciplinary approach to provide the foundations and recommendations for future research into sex- and gender-specific drivers of resilience, including a sex/gender-oriented review of risk factors, geneti

SUBMITTER: Arenaza-Urquijo EM 

PROVIDER: S-EPMC11350140 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature