Dataset Information

Association of Thallium Exposure with Decreased Renal Function among Chinese Adults - China, 2017-2018.

ABSTRACT:

What is already known about this topic?

Thallium (Tl) is significantly more toxic than heavy metals such as lead, cadmium, and mercury. However, previous studies examining the relationship between Tl exposure and the risk of chronic kidney disease (CKD) have yielded inconsistent results.

What is added by this report?

The study demonstrated that elevated urinary Tl levels were associated with a higher prevalence of CKD and a reduced estimated glomerular filtration rate (eGFR), particularly among older adults. These findings were consistent in the restricted cubic spline (RCS) analyses.

What are the implications for public health practice?

This study identified Tl as a risk factor for decreased renal function, underscoring the need to enhance surveillance of Tl to mitigate the disease burden of CKD.

SUBMITTER: Zhang Z

PROVIDER: S-EPMC11350231 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Publications

Association of Thallium Exposure with Decreased Renal Function among Chinese Adults - China, 2017-2018.

Zhang Zheng Z Zhang Miao M Qu Yingli Y Zhao Feng F Ji Saisai S Li Zheng Z Wu Bing B Lyu Chunxian C Song Haocan H Sun Qi Q Li Yawei Y Zhang Xu X Zheng Xulin X Qiu Yidan Y Lu Zihan Z Fu Hui H Xu Lanjing L Zhang Wenli W Luo Yufei Y Li Fangyu F Cai Jiayi J Zhu Yuanduo Y Zhu Ying Y Cao Zhaojin Z Lyu Yuebin Y Shi Xiaoming X

China CDC weekly 20240801 34

<h4>What is already known about this topic?</h4>Thallium (Tl) is significantly more toxic than heavy metals such as lead, cadmium, and mercury. However, previous studies examining the relationship between Tl exposure and the risk of chronic kidney disease (CKD) have yielded inconsistent results.<h4>What is added by this report?</h4>The study demonstrated that elevated urinary Tl levels were associated with a higher prevalence of CKD and a reduced estimated glomerular filtration rate (eGFR), part ...[more]

PMID: 39211414

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Project description:IntroductionEvidence suggests that individuals with a history of adverse childhood experiences have higher odds of developing kidney disease than individuals with no adverse childhood experiences. However, no study has examined the influence of coexisting adverse childhood experiences and kidney disease on mortality risk. This study uses a longitudinal survey of adults to examine the influence of coexisting adverse childhood experiences and decreased renal function on all-cause mortality in a sample of U.S. adults.MethodsA total of 1,205 adults participating in the Midlife Development in the United States series between 1995 and 2014 were used for this analysis performed in 2019. A total of 6 types of adverse childhood experiences were available in the data set, which were combined to create a dichotomous variable with any adverse experience counted as yes. Decreased renal function was defined as an estimated glomerular filtration rate <60 milliliter/minute/1.73 m2. The main outcome was all-cause mortality. Cox proportional hazards models were performed to examine 4 combinations of adverse childhood experiences and decreased renal function associated with overall survival (neither, adverse childhood experiences only, decreased renal function only, or both) controlling for covariables.ResultsIn fully adjusted models, adverse childhood experiences and decreased renal function were associated with increased all-cause mortality relative to neither (hazard ratio=2.85, 95% CI=1.30, 6.25). Decreased renal function only and adverse childhood experiences only were not significantly associated with all-cause mortality (hazard ratio=1.14, 95% CI=0.64, 2.04 and hazard ratio=1.55, 95% CI=0.44, 5.41, respectively). When using decreased renal function as the reference group, coexisting adverse childhood experiences and decreased renal function was associated with a 64% increased risk of all-cause mortality, though this relationship was not statistically significant.ConclusionsCoexistence of adverse childhood experiences and decreased renal function is associated with higher all-cause mortality than seen in individuals with neither adverse childhood experiences nor decreased renal function and may be associated with higher all-cause mortality than seen in individuals with decreased renal function alone. Future research is needed to better understand this potential association.

Dataset Information

Association of Thallium Exposure with Decreased Renal Function among Chinese Adults - China, 2017-2018.

What is already known about this topic?

What is added by this report?

What are the implications for public health practice?

Publications

Association of Thallium Exposure with Decreased Renal Function among Chinese Adults - China, 2017-2018.

Similar Datasets

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