Resistance against aminoglycoside antibiotics via drug or target modification enables community-wide antiphage defense.

ABSTRACT: The ongoing arms race between bacteria and phages has forced bacteria to evolve a sophisticated set of antiphage defense mechanisms that constitute the bacterial immune system. In our previous study, we highlighted the antiphage properties of aminoglycoside antibiotics, which are naturally secreted by Streptomyces. Successful inhibition of phage infection was achieved by addition of pure compounds and supernatants from a natural producer strain emphasizing the potential for community-wide antiphage defense. However, given the dual functionality of these compounds, neighboring bacterial cells require resistance to the antibacterial activity of aminoglycosides to benefit from the protection they confer against phages. In this study, we tested a variety of different aminoglycoside resi

SUBMITTER: Kever L 

PROVIDER: S-EPMC11350373 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature