ProcCluster^® and procaine hydrochloride inhibit the replication of influenza A virus in vitro.

ABSTRACT:

Introduction

Treatment of influenza A virus infections is currently limited to few direct acting antiviral substances. Repurposing other established pharmaceuticals as antivirals could aid in improving treatment options.

Methods

This study investigates the antiviral properties of ProcCluster^® and procaine hydrochloride, two derivatives of the local anesthetic procaine, in influenza A virus infection of A549, Calu-3 and MDCK cells.

Results

Both substances inhibit replication in all three of these cell lines in multi-cycle experiments. However, cell line-dependent differences in the effects of the substances on viral RNA replication and subsequent protein synthesis, as well as release of progeny viruses in single-cycle experiments can be observed. Both ProcCl

SUBMITTER: Haring C 

PROVIDER: S-EPMC11350405 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature