Targeted proteomic profiling of cardiogenic shock in the cardiac intensive care unit.

ABSTRACT:

Aims

We sought to characterize circulating protein biomarkers associated with cardiogenic shock (CS) using highly multiplex proteomic profiling.

Methods and results

This analysis employed a cross-sectional case-control study design using a biorepository of patients admitted to a cardiac intensive care unit between 2017 and 2020. Cases were patients adjudicated to have CS, and controls were those presenting for cardiac critical care without shock, including subsets of patients with isolated hypotension or heart failure (HF). The Olink platform was used to analyse 359 biomarkers with Bonferroni correction. The analysis included 239 patients presenting for cardiac critical care (69 cases with CS, 170 non-shock controls). A total of 63 biomarkers (17.7%) were significantly assoc

SUBMITTER: Patel SM 

PROVIDER: S-EPMC11350432 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature