Genetic Insights Into Perinatal Outcomes of Maternal Antihypertensive Therapy During Pregnancy.

ABSTRACT:

Importance

Limited information exists regarding the impact of pharmacotherapy in pregnancy due to ethical concerns of unintended fetal harm. Yet, maternal prescriptive drug use for chronic conditions such as hypertension is common.

Objective

To investigate potential causal relationships between perturbing maternal genetic variants influencing antihypertensive drug targets and perinatal outcomes among offspring using mendelian randomization (MR).

Design, setting, and participants

This 2-sample MR study used individual-level single-nucleotide variation (SNV) outcome data from mother-father-offspring trios with complete genetic and phenotypic information from the Norwegian Mother, Father and Child Cohort Study (MoBa) and summary-level SNV exposure data from UK Biobank pa

SUBMITTER: Barry CS 

PROVIDER: S-EPMC11350473 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature