Specifically Targeting Capture and Photoinactivation of Viruses through Phosphatidylcholine-Ganglioside Vesicles with Photosensitizer.

ABSTRACT: Herein, we performed a simple virus capture and photoinactivation procedure using visible light on phosphatidylcholine vesicles. l-α-Phosphatidylcholine vesicles were enriched by viral receptors, GT1b gangliosides, and the nonpolar photosensitizer 5,10,15,20-tetraphenylporphyrin. These vesicles absorb in the blue region of visible light with a high quantum yield of antiviral singlet oxygen, O₂ (¹Δ_g). Through the successful incorporation of gangliosides into the structure of vesicles and the encapsulation of photosensitizers in their photoactive and monomeric state, the photogeneration of O₂(¹Δ_g) was achieved with high efficiency on demand; this process was triggered by light, and specifically targeting/inactivating viruses w

SUBMITTER: Hornikova L 

PROVIDER: S-EPMC11350727 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature