Targeting N-Acetylglucosaminidase in Staphylococcus aureus with Iminosugar Inhibitors.

ABSTRACT: Bacteria are capable of remarkable adaptations to their environment, including undesirable bacterial resistance to antibacterial agents. One of the most serious cases is an infection caused by multidrug-resistant Staphylococcus aureus, which has unfortunately also spread outside hospitals. Therefore, the development of new effective antibacterial agents is extremely important to solve the increasing problem of bacterial resistance. The bacteriolytic enzyme autolysin E (AtlE) is a promising new drug target as it plays a key role in the degradation of peptidoglycan in the bacterial cell wall. Consequently, disruption of function can have an immense impact on bacterial growth and survival. An in silico and in vitro evaluation of iminosugar derivatives as potent inhibitors of S. aure

SUBMITTER: Sluga J 

PROVIDER: S-EPMC11350809 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature