On the informative value of community-based indoor radon values in relation to lung cancer.

ABSTRACT:

Background

Radon is a radioactive gas and a major risk factor for lung cancer (LC).

Methods

We investigated the dose-response relationship between radon and LC risk in the International Lung Cancer Consortium with 8927 cases and 5562 controls from Europe, North America, and Israel, conducted between 1992 and 2016. Spatial indoor radon exposure in the residential area (sIR) obtained from national surveys was linked to the participants' residential geolocation. Parametric linear and spline functions were fitted within a logistic regression framework.

Results

We observed a non-linear spatial-dose response relationship for sIR < 200 Bq/m³. The lowest risk was observed for areas of mean exposure of 58 Bq/m³ (95% CI: 56.1-59.2 Bq/m³). The re

SUBMITTER: Rosenberger A 

PROVIDER: S-EPMC11350838 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature