A Real-World Data Observational Analysis of the Impact of Liposomal Amphotericin B on Renal Function Using Machine Learning in Critically Ill Patients.

ABSTRACT:

Background

Liposomal amphotericin B (L-AmB) has become the mainstay of treatment for severe invasive fungal infections. However, the potential for renal toxicity must be considered.

Aims

To evaluate the incidence of acute kidney injury (AKI) in critically ill patients receiving L-AmB for more than 48 h.

Methods

Retrospective, observational, single-center study. Clinical, demographic and laboratory variables were obtained automatically from the electronic medical record. AKI incidence was analyzed in the entire population and in patients with a "low" or "high" risk of AKI based on their creatinine levels at the outset of the study. Factors associated with the development of AKI were studied using random forest models.

Results

Finally, 67 patients with a median a

SUBMITTER: Sacanella I 

PROVIDER: S-EPMC11350854 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature