Gut microbiota contributes to high-altitude hypoxia acclimatization of human populations.

ABSTRACT:

Background

The relationship between human gut microbiota and high-altitude hypoxia acclimatization remains highly controversial. This stems primarily from uncertainties regarding both the potential temporal changes in the microbiota under such conditions and the existence of any dominant or core bacteria that may assist in host acclimatization.

Results

To address these issues, and to control for variables commonly present in previous studies which significantly impact the results obtained, namely genetic background, ethnicity, lifestyle, and diet, we conducted a 108-day longitudinal study on the same cohort comprising 45 healthy Han adults who traveled from lowland Chongqing, 243 masl, to high-altitude plateau Lhasa, Xizang, 3658 masl, and back. Using shotgun metagenomic pro

SUBMITTER: Su Q 

PROVIDER: S-EPMC11350960 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature