Association of telomerase reverse transcriptase gene rs10069690 variant with cancer risk: an updated meta-analysis.

ABSTRACT:

Objective

Existing evidence suggests telomerase activation is a crucial step in tumorigenesis. The telomerase reverse transcriptase (TERT), encoded by the human TERT gene, is critical for telomerase expression. The TERT rs10069690 (C > T) variant was identified to be associated with the risk of cancer, however, there have been inconsistent results. Therefore, we performed a comprehensive meta-analysis aiming to clarify the association between this variant and cancer susceptibility.

Methods

We conducted literature search in PubMed, EMbase, MEDLINE and Cochrane Library up to April 30, 2024. Overall, there are 55 studies involving 334,196 patients with cancer and 741,187 controls included in the present study. All statistical analyses were performed by STATA software (version 1

SUBMITTER: Zhou C 

PROVIDER: S-EPMC11350973 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature