Ribosome Tunnel Environment Drives the Formation of α-Helix during Cotranslational Folding.

ABSTRACT: Protein conformations in cells are not solely determined by amino acid sequences; they also depend on cellular environments. For instance, the ribosome tunnel induces its specific α-helix formation during cotranslational folding. Owing to the link between these temporally α-helix and biological functions, the mechanism of α-helix formation inside the ribosome tunnel has been previously explored. Consequently, the conformational restrictions of the tunnel were considered one of the driving forces of α-helix formation. Conversely, the ribosomal tunnel environment, including its chemical properties, appears to influence the α-helix formation. However, a comprehensive analysis of the ribosome tunnel environment's impact on the α-helix formation has not been conducted yet due to challenges in e

SUBMITTER: Yasuda T 

PROVIDER: S-EPMC11351022 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature