Clofazimine inhibits innate immunity against Mycobacterium tuberculosis by NF-κB.

ABSTRACT: Tuberculosis (TB) remains one of the infectious diseases with high incidence and high mortality. About a quarter of the population has been latently infected with Mycobacterium tuberculosis. At present, the available TB treatment strategies have the disadvantages of too long treatment duration and serious adverse reactions. The sustained inflammatory response leads to permanent tissue damage. Unfortunately, the current selection of treatment regimens does not consider the immunomodulatory effects of various drugs. In this study, we preliminarily evaluated the effects of commonly used anti-tuberculosis drugs on innate immunity at the cellular level. The results showed that clofazimine (CFZ) has a significant innate immunosuppressive effect. CFZ significantly inhibited cytokines and t

SUBMITTER: Li X 

PROVIDER: S-EPMC11351037 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature