The role of miR-155-5p in inflammation and mechanical loading during intervertebral disc degeneration.

ABSTRACT:

Background

Intervertebral disc (IVD) degeneration is a multifactorial pathological process resulting in the dysregulation of IVD cell activity. The catabolic shift observed in IVD cells during degeneration leads to increased inflammation, extracellular matrix (ECM) degradation, aberrant intracellular signaling and cell loss. Importantly, these pathological processes are known to be interconnected and to collectively contribute to the progression of the disease. MicroRNAs (miRNAs) are known as strong post-transcriptional regulators, targeting multiple genes simultaneously and regulating numerous intracellular pathways. Specifically, miR-155-5p has been of particular interest since it is known as a pro-inflammatory mediator and contributing factor to diseases like cancer and osteoart

SUBMITTER: Cazzanelli P 

PROVIDER: S-EPMC11351051 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature