Measuring Geographic Atrophy Area Using Column-Based Machine Learning Software on Spectral-Domain Optical Coherence Tomography versus Fundus Auto Fluorescence.

ABSTRACT:

Background

The purpose of this study was to compare geographic atrophy (GA) area semi-automatic measurement using fundus autofluorescence (FAF) versus optical coherence tomography (OCT) annotation with the cRORA (complete retinal pigment epithelium and outer retinal atrophy) criteria.

Methods

GA findings on FAF and OCT were semi-automatically annotated at a single time point in 36 pairs of FAF and OCT scans obtained from 36 eyes in 24 patients with dry age-related macular degeneration (AMD). The GA area, focality, perimeter, circularity, minimum and maximum Feret diameter, and minimum distance from the center were compared between FAF and OCT annotations.

Results

The total GA area measured on OCT was 4.74 ± 3.80 mm². In contrast, the total GA measured on FA

SUBMITTER: Shmueli O 

PROVIDER: S-EPMC11351153 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature