Prognostic Significance of VAV3 Gene Variants and Expression in Renal Cell Carcinoma.

ABSTRACT: Renal cell carcinoma (RCC) is characterized by high mortality and morbidity rates. Vav guanine nucleotide exchange factors (VAVs), crucial for signal transduction between cell membrane receptors and intracellular mediators, have been implicated in carcinogenesis. However, their potential prognostic value in RCC remains unclear. The impact of 150 common VAV polymorphisms on RCC risk and survival was investigated in a cohort of 630 individuals. Publicly available gene expression datasets were utilized to analyze VAV gene expression in relation to patient outcomes. The VAV3 rs17019888 polymorphism was significantly associated with RCC risk and overall survival after adjusting for false discovery rates. Expression quantitative trait loci analysis revealed that the risk all

SUBMITTER: Chang CF 

PROVIDER: S-EPMC11351164 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature