Investigating the Relationship between Epigenetic Age and Cardiovascular Risk in a Population with Overweight/Obesity.

ABSTRACT: Introduction: Cardiovascular diseases stand as the leading global cause of mortality. Major modifiable risk factors encompass overweight/obese conditions, high blood pressure, elevated LDL cholesterol, diabetes, smoking, secondhand smoke exposure, unhealthy diet, and physical inactivity. In the present study, we explored the relationship between cardiovascular risk factors and epigenetic age (DNAm age), an estimate reflecting an individual's actual physiological functionality and overall health. Additionally, we assessed the association between DNAm age acceleration and cardiovascular risk, as evaluated through the Framingham risk score (FRS). Methods: The study includes 190 subjects with overweight/obese conditions. We calculated their DNAm age using Zbieć-Piekarska et al.'s

SUBMITTER: Marinello D 

PROVIDER: S-EPMC11351200 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature