Differential white blood cell count and epigenetic clocks: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

Human aging and white blood cell (WBC) count are complex traits influenced by multiple genetic factors. Predictors of chronological age have been developed using epigenetic clocks. However, the bidirectional causal effects between epigenetic clocks and WBC count have not been fully examined.

Methods

This study employed Mendelian randomization (MR) to analyze summary statistics from four epigenetic clocks involving 34,710 participants, alongside data from the Blood Cell Consortium encompassing 563,946 individuals. We primarily explored bidirectional causal relationships using the random-effects inverse-variance weighted method, supplemented by additional MR methods for comprehensive analysis. Additionally, multivariate MR was applied to investigate independent effe

SUBMITTER: Sun M 

PROVIDER: S-EPMC11351201 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature