Sterigmatocystin declines mouse oocyte quality by inducing ferroptosis and asymmetric division defects.

ABSTRACT:

Background

Sterigmatocystin (STE) is a mycotoxin widely found in contaminated food and foodstuffs, and excessive long-term exposure to STE is associated with several health issues, including infertility. However, there is little information available regarding the effects of STE toxin on the female reproductive system, particularly concerning oocyte maturation.

Methods

In the present study, we investigated the toxic effects of STE on mouse oocyte maturation. We also used Western blot, immunofluorescence, and image quantification analyses to assess the impact of STE exposure on the oocyte maturation progression, mitochondrial distribution, oxidative stress, DNA damages, oocyte ferroptosis and asymmetric division defects.

Results

Our results revealed that STE exposure d

SUBMITTER: Wang S 

PROVIDER: S-EPMC11351269 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature