Developing a validated methodology for identifying clozapine treatment periods in electronic health records.

ABSTRACT:

Background

Clozapine is the only recommended antipsychotic medication for individuals diagnosed with treatment-resistant schizophrenia. Unfortunately, its wider use is hindered by several possible adverse effects, some of which are rare but potentially life threatening. As such, there is a growing interest in studying clozapine use and safety in routinely collected healthcare data. However, previous attempts to characterise clozapine treatment have had low accuracy.

Aim

To develop a methodology for identifying clozapine treatment dates by combining several data sources and implement this on a large clinical database.

Methods

Non-identifiable electronic health records from a large mental health provider in London and a linked database from a national clozapine blood mo

SUBMITTER: Segev A 

PROVIDER: S-EPMC11351314 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature