Prognostic impact of body composition in hepatocellular carcinoma patients with immunotherapy.

ABSTRACT:

Objective

This study aims to examine the possible relationship between body composition parameters, sarcopenia, and clinical outcomes in hepatocellular carcinoma (HCC) patients who received immune checkpoint inhibitor (ICI) treatment.

Methods

Three online databases, including Embase, PubMed, and the Cochrane Library, were thoroughly searched for literature describing the relationship between body composition parameters, sarcopenia, and outcomes of ICI-treated HCC patients from the start of each database to 21 January 2024. The Newcastle-Ottawa Scale was used to rate the quality of the studies. The assessed outcomes included hazard ratio (HR) for OS and PFS, as well as odds ratio (OR) for ORR and DCR.

Results

This analysis included a total of 15 articles with a combine

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11351359 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature