Vaginal and endometrial microbiome dysbiosis associated with adverse embryo transfer outcomes.

ABSTRACT:

Background

Assisted reproductive technology (ART) is the most effective method to treat infertility and the pathogenesis of implantation failure after in vitro fertilization-embryo transfer (IVF-ET) is a challenging filed in infertility. Microbes in the female reproductive tract are considered to be associated with gynecological and obstetric diseases. However, its effects on embryo implantation failure are unsured.

Purpose

This study aimed to investigate reproductive tract dysbiosis, identify different bacteria in reproductive tract as potential biomarkers of embryo implantation failure and demonstrate the pathogenesis through metabolites analysis.

Methods

We compared the data from 16S rRNA gene and metagenome in reproductive tracts through QIIME2 and HUMAnN2 by the

SUBMITTER: Su W 

PROVIDER: S-EPMC11351450 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature