Characterization of a Novel Oxidative Stress Responsive Transcription Regulator in Mycobacterium bovis.

ABSTRACT: The antioxidant defense is critical for the survival of intracellular pathogens such as Mycobacterium tuberculosis complex (MTBC) species, including Mycobacterium bovis, which are often exposed to an oxidative environment caused by reactive oxygen species (ROS) in hosts. However, the signaling pathway in mycobacteria for sensing and responding to oxidative stress remains largely unclear. In this study, we characterize a TetR-type transcription regulator BCG_3893c, designated AotM, as a novel redox sensor in Mycobacterium bovis that increases mycobacterial tolerance to oxidative stress. AotM is required for the growth of M. bovis in the presence of 1 mM hydrogen peroxide. Loss of the aotM gene leads to altered transcriptional profiles with 352 genes signif

SUBMITTER: Jiang Q 

PROVIDER: S-EPMC11351531 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature