Heat-killed Bifidobacterium longum BBMN68 and inulin protect against high-fat diet-induced obesity by modulating gut microbiota.

ABSTRACT:

Introduction

Obesity, a pervasive global epidemic, has heightened susceptibility to chronic ailments and diminished the overall life expectancy on a global scale. Probiotics and inulin (IN) have been documented to mitigate obesity by exerting an influence on the composition of the gut microbiota. Whether heat-killed Bifidobacterium longum BBMN68 (MN68) and IN have an anti-obesity effect remains to be investigated.

Methods

In this study, Wistar rats were fed a high-fat diet (HFD), and orally administered heat-killed MN68 (2 × 10¹¹ CFU/kg) and/or inulin (0.25 kg/kg) for 12 weeks. Histological analysis, serology analysis and 16S rRNA gene sequencing were performed.

Results

Heat-killed MN68 + IN treatment showed an enhanced effect on preventing weight ga

SUBMITTER: Sun S 

PROVIDER: S-EPMC11351561 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature