Causal effect of lifestyle and metabolic indicator with herpes zoster: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Previous observational studies have reported certain causal relationships between factors such as smoking, alcohol consumption, obesity, physical activity, metabolic disorders, and the incidence of herpes zoster (HZ). However, there is controversy regarding the observed results across different studies. Our objective was to investigate the causal effects of these risk factors on the risk of herpes zoster through a Mendelian randomization analysis using two-sample bidirectional approaches.

Methods

We conducted two-sample bidirectional Mendelian randomization analyses to explore the causal relationships between different lifestyles, obesity assessment indices, metabolic indicators, and the risk of herpes zoster. All exposure and outcome data were sourced from public

SUBMITTER: Huang M 

PROVIDER: S-EPMC11351565 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature