Quantitative Aspect of Bacillus subtilis σ^B Regulatory Network on a Proteome Level-A Computational Simulation.

ABSTRACT: Bacillus subtilis is a model organism used to study molecular processes in Gram-positive bacteria. Sigma factor B, which associates with RNA polymerase, is one of the transcriptional regulators involved in the cell's response to environmental stress. Experiments have proven that the amounts of free σ^B (SigB) are controlled by a system of anti- (RsbW) and anti-anti-sigma (RsbV) factors expressed from the same operon as SigB. Moreover, the phosphorylation state of RsbV is controlled by phosphatases RsbP and RsbU, which directly dephosphorylate RsbV. A set of chemical equations describing the network controlling the levels of free SigB was converted to a set of differential equations quantifying the dynamics of the network. The solution of these equations allowed the simulat

SUBMITTER: Vohradsky J 

PROVIDER: S-EPMC11351616 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature