Is Cadmium Genotoxicity Due to the Induction of Redox Stress and Inflammation? A Systematic Review.

ABSTRACT: The transition metal cadmium (Cd) is toxic to humans and can induce cellular redox stress and inflammation. Cd is a recognized carcinogen, but the molecular mechanisms associated with its genotoxicity and carcinogenicity are not defined. Therefore, a systematic review was undertaken to examine the scientific literature that has covered the molecular mechanism of Cd genotoxicity and its relationship to cellular redox stress and inflammation. An electronic database search of PubMed, Scopus, and the Web of Science Core Collection was conducted to retrieve the studies that had investigated if Cd genotoxicity was directly linked to the induction of redox stress and inflammation. Studies included exposure to Cd via in vitro and in vivo routes of administration. Of 214 publications retrieved, 10

SUBMITTER: Badawi K 

PROVIDER: S-EPMC11351676 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature