Structural Magnetic Resonance Imaging-Based Surface Morphometry Analysis of Pediatric Down Syndrome.

ABSTRACT: Down syndrome (DS) is a genetic disorder characterized by intellectual disability whose etiology includes an additional partial or full copy of chromosome 21. Brain surface morphometry analyses can potentially assist in providing a better understanding of structural brain differences, and may help characterize DS-specific neurodevelopment. We performed a retrospective surface morphometry study of 73 magnetic resonance imaging (MRI) examinations of DS patients (aged 1 day to 22 years) and compared them to a large cohort of 993 brain MRI examinations of neurotypical participants, aged 1 day to 32 years. Surface curvature measurements, absolute surface area measurements, and surface areas as a percentage of total brain surface area (%TBSA) were extracted from each brain region in each examina

SUBMITTER: Levman J 

PROVIDER: S-EPMC11351698 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature