Combined Effects of Nasal Ketamine and Trauma-Focused Psychotherapy in Treatment-Resistant Post-Traumatic Stress Disorder: A Pilot Case Series.

ABSTRACT:

Objective

This pilot case series investigated the feasibility and efficacy of an eight-week therapy program, combining nasally administered ketamine (0.5 mg/kg) with trauma-focused psychotherapy, for individuals with chronic, treatment-resistant post-traumatic stress disorder (PTSD).

Method

Three patients with chronic, treatment-resistant PTSD underwent the eight-week therapy program. Clinical assessments included the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) and the Hamilton Depression Rating Scale (HAMD) at baseline, post-assessment, and follow-up assessment, along with additional measures assessing other relevant symptoms and side effects.

Results

The results demonstrated clinically relevant reductions in PTSD symptoms, indicated by a change in the CAPS-

SUBMITTER: Rohde J 

PROVIDER: S-EPMC11351759 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature