Identification of Clinical Value and Biological Effects of XIRP2 Mutation in Hepatocellular Carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is a prevalent malignant digestive tumor. Numerous genetic mutations have been documented in HCC, yet the clinical significance of these mutations remains largely unexplored. The objective of this study is to ascertain the clinical value and biological effects of xin actin binding repeat containing 2 (XIRP2) mutation in HCC. The gene mutation landscape of HCC was examined using data from the Cancer Genome Atlas and the International Cancer Genome Consortium databases. The prognostic significance of the XIRP2 mutation was assessed through KM plot analysis. The association between drug sensitivity and the XIRP2 mutation was investigated using the TIDE algorithm and CCK-8 experiments. The biological effects of the XIRP2 mutation were

SUBMITTER: Li D 

PROVIDER: S-EPMC11351838 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature