The Pros and Cons of Estrogens in Prostate Cancer: An Update with a Focus on Phytoestrogens.

ABSTRACT: The role of estrogens in prostate cancer (PCa) is shrouded in mystery, with its actions going from angelic to devilish. The findings by Huggins and Hodges establishing PCa as a hormone-sensitive cancer have provided the basis for using estrogens in therapy. However, despite the clinical efficacy in suppressing tumor growth and the panoply of experimental evidence describing its anticarcinogenic effects, estrogens were abolished from PCa treatment because of the adverse secondary effects. Notwithstanding, research work over the years has continued investigating the effects of estrogens, reporting their pros and cons in prostate carcinogenesis. In contrast with the beneficial therapeutic effects, many reports have implicated estrogens in the disruption of prostate cell fate and tissue homeos

SUBMITTER: Figueira MI 

PROVIDER: S-EPMC11351860 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature