Diagnostic Value of Menstrual Blood Lipidomics in Endometriosis: A Pilot Study.

ABSTRACT: Endometriosis is a prevalent chronic inflammatory disease characterized by a considerable delay between initial symptoms and diagnosis through surgery. The pressing need for a timely, non-invasive diagnostic solution underscores the focus of current research efforts. This study examines the diagnostic potential of the menstrual blood lipidome. The lipid profile of 39 samples (23 women with endometriosis and 16 patients in a control group) was acquired using reverse-phase high-performance liquid chromatography-mass spectrometry with LipidMatch processing and identification. Profiles were normalized based on total ion counts. Significant differences in lipids were determined using the Mann-Whitney test. Lipids for the diagnostic model, based on logistic regression, were selected using a comb

SUBMITTER: Starodubtseva N 

PROVIDER: S-EPMC11351896 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature