Photobiomodulation Mitigates PM_2.5-Exacerbated Pathologies in a Mouse Model of Allergic Asthma.

ABSTRACT: Exposure to particulate matter (PM), especially PM_2.5, is known to exacerbate asthma, posing a significant public health risk. This study investigated the asthma-reducing effects of photobiomodulation (PBM) in a mice model mimicking allergic airway inflammation exacerbated by PM_2.5 exposure. The mice received sensitization with ovalbumin (OVA) and were subsequently treated with PM_2.5 at a dose of 0.1 mg/kg every 3 days, for 9 times over 3 weeks during the challenge. PBM, using a 610 nm wavelength LED, was applied at 1.7 mW/cm² to the respiratory tract via direct skin contact for 20 min daily for 19 days. Results showed that PBM significantly reduced airway hyperresponsiveness, plasma immunoglobulin E (IgE) and OVA-specific IgE, airway inflammatio

SUBMITTER: Park J 

PROVIDER: S-EPMC11351905 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature