Combined Effects of Fibroblast Growth Factor-2 and Carbonate Apatite Granules on Periodontal Healing: An In Vivo and In Vitro Study.

ABSTRACT: The aim of this study was to investigate in vivo and in vitro the effectiveness of the use of fibroblast growth factor (FGF)-2 with carbonate apatite (CO₃Ap) on periodontal healing. Periodontal defects created in the maxillary first molars in rats were treated with FGF-2, CO₃Ap, FGF-2 + CO₃Ap or left unfilled. Healing was evaluated using microcomputed tomography, histological, and immunohistochemical analyses. In vitro experiments were performed to assess cellular behaviors and the expression of osteoblastic differentiation markers in MC3T3-E1 cells. At 4 weeks, the bone volume fraction in the FGF-2 + CO₃Ap group was significantly greater than that in the CO₃Ap group, but there was no significant difference from the FGF-2 group. The FG

SUBMITTER: Miyata N 

PROVIDER: S-EPMC11352071 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature