Higher Circulating Neutrophil Counts Is Associated with Increased Risk of All-Cause Mortality and Cardiovascular Disease in Patients with Diabetic Kidney Disease.

ABSTRACT:

Background

Accumulating evidence has suggested the pathogenic roles of chronic inflammation and neutrophils in diabetic kidney disease (DKD). This study investigated the relationship between neutrophils, all-cause, and cardiovascular disease (CVD) mortality in type 2 diabetes mellitus (T2DM) patients with DKD.

Methods

We used data from the National Health and Nutrition Examination Surveys (NHANES) from 2005 to 2020 to investigate the relationship between circulating neutrophils counts, kidney function indices, all-cause, and CVD mortality in adult T2DM patients with DKD. Clinical predictive models and risk scores for long-term mortality were constructed.

Results

44,332 patients [8034 with T2DM and 36,323 without T2DM] were included. Two thousand two hundred twenty pat

SUBMITTER: Xie R 

PROVIDER: S-EPMC11352130 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature