Integrated Multi-Omics Analysis of Cerebrospinal Fluid in Postoperative Delirium.

ABSTRACT: Preoperative risk biomarkers for delirium may aid in identifying high-risk patients and developing intervention therapies, which would minimize the health and economic burden of postoperative delirium. Previous studies have typically used single omics approaches to identify such biomarkers. Preoperative cerebrospinal fluid (CSF) from the Healthier Postoperative Recovery study of adults ≥ 63 years old undergoing elective major orthopedic surgery was used in a matched pair delirium case-no delirium control design. We performed metabolomics and lipidomics, which were combined with our previously reported proteomics results on the same samples. Differential expression, clustering, classification, and systems biology analyses were applied to individual and combined omics datasets. Probabilistic

SUBMITTER: Tripp BA 

PROVIDER: S-EPMC11352186 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature