Nanosensor-Enabled Detection and Identification of Intracellular Bacterial Infections in Macrophages.

ABSTRACT: Opportunistic bacterial pathogens can evade the immune response by residing and reproducing within host immune cells, including macrophages. These intracellular infections provide reservoirs for pathogens that enhance the progression of infections and inhibit therapeutic strategies. Current sensing strategies for intracellular infections generally use immunosensing of specific biomarkers on the cell surface or polymerase chain reaction (PCR) of the corresponding nucleic acids, making detection difficult, time-consuming, and challenging to generalize. Intracellular infections can induce changes in macrophage glycosylation, providing a potential strategy for signature-based detection of intracellular infections. We report here the detection of bacterial infection in macrophages using a boron

SUBMITTER: Chattopadhyay AN 

PROVIDER: S-EPMC11352223 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature