The Personalized Inherited Signature Predisposing to Non-Small-Cell Lung Cancer in Non-Smokers.

ABSTRACT: Lung cancer (LC) continues to be an important public health problem, being the most common form of cancer and a major cause of cancer deaths worldwide. Despite the great bulk of research to identify genetic susceptibility genes by genome-wide association studies, only few loci associated to nicotine dependence have been consistently replicated. Our previously published study in few phenotypically discordant sib-pairs identified a combination of germline truncating mutations in known cancer susceptibility genes in never-smoker early-onset LC patients, which does not present in their healthy sib. These results firstly demonstrated the presence of an oligogenic combination of disrupted cancer-predisposing genes in non-smokers patients, giving experimental support to a model of a "private gene

SUBMITTER: Serio VB 

PROVIDER: S-EPMC11352340 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature