Exploring a Novel Role of Glycerol Kinase 1 in Prostate Cancer PC-3 Cells.

ABSTRACT: Clinically, prostate cancer is infamous for its histological and molecular heterogeneity, which causes great challenges to pinpoint therapy and pharmaceutical development. To overcome these difficulties, researchers are focusing on modulating tumor microenvironment and immune responses in addition to genetic alteration and epigenetic regulation. Here, we aimed to identify potential biomarkers or modulators of prostate cancer by investigating genes specifically altered in prostate cancer cells treated with established anti-cancer agents. Glycerol kinase 1 (GK1) is phosphotransferase encoded on the X chromosome, is associated with the synthesis of triglycerides and glycerophospholipids, and has been mainly studied for X-linked metabolic disorder GK deficiency (GKD). Interestingly, our DNA mi

SUBMITTER: Park B 

PROVIDER: S-EPMC11352368 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature