Multiscale Modeling of Bistability in the Yeast Polarity Circuit.

ABSTRACT: Cell polarity refers to the asymmetric distribution of proteins and other molecules along a specified axis within a cell. Polarity establishment is the first step in many cellular processes. For example, directed growth or migration requires the formation of a cell front and back. In many cases, polarity occurs in the absence of spatial cues. That is, the cell undergoes symmetry breaking. Understanding the molecular mechanisms that allow cells to break symmetry and polarize requires computational models that span multiple spatial and temporal scales. Here, we apply a multiscale modeling approach to examine the polarity circuit of yeast. In addition to symmetry breaking, experiments revealed two key features of the yeast polarity circuit: bistability and rapid dismantling of the polarity si

SUBMITTER: Hladyshau S 

PROVIDER: S-EPMC11352540 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature